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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • The Nervous System

    Autonomic Nervous System Drugs
    • 1st Edition
    • Walter S. Root + 1 more
    • English
    Physiological Pharmacology: A Comprehensive Treatise, Volume III: The Nervous System — Part C: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including cardiovascular effects and metabolism. The selection first offers information on the cardiovascular effects of choline esters and the effects of choline esters on smooth muscles and secretions. Topics include actions of acetylcholine, physiological role of choline esters, and actions of cholinergic drugs on smooth muscles and secretions. The book also takes a look at the pharmacologic, toxicologic, and therapeutic properties of anticholinesterase agents, including the chemistry and metabolism of anticholinesterase substances and mechanisms of action of anticholinesterase agents and role of cholinesterases. The publication examines muscarinic blocking drugs and ganglion-blocking drugs. Discussions focus on actions on the secretory glands and cardiovascular system; distribution, metabolism, and excretion of atropine; substances that block ganglionic transmission; and cardiovascular effects. The text also elaborates on neuromuscular blocking drugs. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.

  • Epidemiology of Leukaemia and Lymphoma

    Report of the Leukaemia Research Fund International Workshop, Oxford, UK, September 1984
    • 1st Edition
    • M. F. Greaves + 1 more
    • English
    Epidemiology of Leukaemia and Lymphoma contains the proceedings of the Leukaemia Research Fund International Workshop held in Oxford, UK, on September 25-27, 1984. Contributors explore the epidemiology of leukemia and lymphoma based on the results of a pilot study that investigated whether careful subdivision of acute lymphoblastic leukemia (ALL) using a standardized panel of monoclonal antibodies would reveal interesting associations between subtypes and particular geographic regions or ethnic groups within regions. This book is comprised of 31 chapters divided into four sections and begins with a discussion on epidemiological approaches to hematological malignancy, paying particular attention to international data collection and interpretation; clusters and associations in cancer epidemiology; and childhood leukemia in Great Britain and the Netherlands. The next section explores the causes of human leukemia and lymphoma as well as the epidemiology of leukemia and lymphoma subtypes in various regions of the world such as Africa, Asia, United States, and Mediterranean region. The final section focuses on practical problems in standardized immunophenotyping of leukemias and lymphomas; immuno-alkaline phosphatase labeling of hematological samples; and detection of surface membrane antigens by a rosette assay using antibody coupled red cells. This monograph will be of value to clinicians and medical practitioners interested in the epidemiology of leukemia and lymphoma.

  • Bioreduction in the Activation of Drugs

    Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25-26 July 1985
    • 1st Edition
    • P. Alexander + 2 more
    • English
    Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.

  • Mechanisms of Drug Toxicity

    Proceedings of the Third International Pharmacological Meeting
    • 1st Edition
    • H. Rašková
    • English
    Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

  • CNS and Behavioural Pharmacology

    Proceedings of the Sixth International Congress of Pharmacology
    • 1st Edition
    • M. Airaksinen
    • English
    CNS and Behavioural Pharmacology is the third volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. Contributors focus on the findings concerning the central nervous system (CNS) and on the developments in behavioral pharmacology and related areas of research. This volume has 33 chapters divided into five sections. After discussing the application of psychopharmacology to the conservation of wild animals such as ungulates, this book turns its attention to alcohol dependence and the interactions between neurotransmitters and the hypothalamic releasing hormones. The reader is methodically introduced to the pharmacology of emotive behavior, with emphasis on drug effects in mental and emotional disorders as well as the action of psychotropic drugs on emotions, motivations, and social behavior of animals. The final section is devoted to the pharmacological aspects of the cerebrospinal fluid-transport system. This section covers topics such as the metabolism of biogenic amines in the human CNS; the importance of dopamine metabolism for the clinical effects and side effects of neuroleptics; and composite transport systems for organic acids and bases in choroid plexus. This book will be of interest to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

  • Pharmacology of Central Synapses

    • 1st Edition
    • V. V. Zakusov
    • English
    Pharmacology of Central Synapses deals with the pharmacology of the central nervous system and the mode of action of neurotropic drugs based on their influence on synaptic transmission. The neuronal structure of the nervous system, the structure of the synapses, and the phenomena of electrochemical transmission are discussed in this context. The main propositions of the synaptic theory of the action of neurotropic drugs, based on morphological, physiological, and biochemical findings, form the conceptual basis of this book. Comprised of eight chapters, this book examines the effect of neurotropic drugs on the synaptic transmission in reflex, projection, and association (commissural) tracts. The specific effects of various narcotics, neuroleptics, tranquillizers, analgesics, antidepressants, and stimulants on synaptic transmission in various structures of the central nervous system and at its different levels are described. This text also considers the differences in the sensitivity to such drugs of various synapses and their influence on the selectivity of drug action. This book explains the influence of neurotropic drugs on such aspects of nervous activity as impulse summation, after-discharge and functional lability, central inhibition, and the neurochemical mechanisms, particularly those involving monoaminergic, cholinergic, serotoninergic, and GABA-ergic components of synaptic transmission. The final chapter focuses on the effect of psychotropic drugs on behavior. This book will be helpful to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

  • The Toxicology of Radioactive Substances

    Volume 5
    • 1st Edition
    • A. A. Letavet + 1 more
    • English
    The Toxicology of Radioactive Substances, Volume 5: Zinc-65 deals with the toxic properties of the radioisotope zinc-65 as well as its biological effects. Emphasis is placed on the role of stable zinc in the reaction of the body to the administration of zinc-65. Some of the results of laboratory studies on the toxic effects of zinc-65 on animals, primarily rabbits, are presented. This volume is comprised of 18 chapters and opens with an overview of certain aspects of the toxicology of radioactive zinc-65, followed by a discussion on the behavior of zinc-65 in the rat body. Subsequent chapters explore the distribution of zinc-65 in the body of rabbits following chronic oral administration; bioelectrical activity of the cerebral cortex in rabbits in conditions of prolonged administration of radioactive zinc; the effect of prolonged internal irradiation with G5ZnCl2 on the functional state of the rabbit heart; and aspects of hemopoiesis following chronic intake of radiozinc. Morphological changes in experimental animals following chronic exposure to radioactive zinc are also considered. This book will be of interest to chemists and toxicologists.

  • Annual Review of Chronopharmacology

    Volume 2
    • 1st Edition
    • A. Reinberg + 2 more
    • English
    Annual Review of Chronopharmacology, Volume 2 presents a scholarly means of rapidly communicating findings and developments in chronopharmacology, which is considered a quickly emerging field. This text first discusses aspects and statistical procedures in chronobiology and chronopharmacology. This book then explains circadian and circannual changes in nephrotoxic effects of heavy metals and antibiotics; chronotoxicology and chronopharmacology with emphasis on carcinostatic agents; and chronopharmacology of cardiovascular medications. The chronopharmacology and chronotherapy of asthma are also tackled. This book concludes by explaining the chronopharmacology of antidepressant drugs and of the inflammatory process. This publication will be invaluable to those interested in the field of chronopharmacology.

  • Advances in Pharmacological Research and Practice

    Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985
    • 1st Edition
    • J. Knoll + 1 more
    • English
    Advances in Pharmacological Research and Practice, Volume 1: Pharmacological Protection of the Myocardium presents the proceedings of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the development in the fields of pharmacological protection of the myocardium and the pharmacology of the vascular system. Organized into two sections encompassing 70 chapters, this volume begins with an overview of the ischemic biochemical changes with emphasis on the role of cAMP and the protein kinase system. This text then explores the cellular electrophysiological disorders seen in acute myocardial ischemia as well as their pharmacological modification. Other chapters consider the prevention of primary ventricular fibrillation that includes measures aimed at maintaining electrical stability. The final chapter deals with drugs affecting beneficially the pathological lipoprotein levels. This book is a valuable resource for cardiologists and pharmacologists.

  • Drugs and Youth: The Challenge of Today

    • 1st Edition
    • Ernest Harms
    • English
    Drugs and Youth: The Challenge of Today mainly focuses on the issue of drug addiction in youth and on how to bring this issue to the knowledge of the concerned sectors. This text first discusses the effects on the fetus and newborn of drug abuse in pregnancy. This book then explains the major drugs adolescents and young adults take, including solvents wherein a survey related to this is also presented in this publication. The effects of these drugs, such as physical and mental illnesses, are also tackled. This text also looks into the approaches in the treatment of adolescent drug addicts, including the withdrawal syndrome, group therapy, and psychotherapy. This book concludes by explaining the religious problematic and aftercare problems with the juvenile drug addict. This publication will be invaluable to medical practitioners, sociologists, social workers, ministers, and students doing a research on drug addiction in youth.

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