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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Marijuana

    Effects on Human Behavior
    • 1st Edition
    • Loren L. Miller
    • English
    Marijuana: Effects on Human Behavior attempts to synthesize much of the existing experimentation concerning the acute and chronic effects of marijuana and its derivatives on human behavior. The book opens with a chapter on the strategies for conducting research on marijuana. It also describes a clinical study at the University of British Columbia. The next chapter discusses the issues that have beclouded the question of legalization of marijuana in the United States. This is followed by separate chapters on the effects of marijuana on motor and mental performance; marijuana-memory research; a model of attention which can be used to describe the effects of marijuana use on cognition; and the effects of marijuana on neuropsychological functioning and learning. Subsequent chapters examine the behavioral actions of cannabis in man; compare the behavioral actions of cannabinoids in humans with those found in infrahumans, with special reference to acquisition and retention processes, timing behavior, state-dependent learning, and attention; and investigate the long-term effects of cannabis use.

  • Microsomes and Drug Oxidations

    • 1st Edition
    • James R. Gillette + 2 more
    • English
    Microsomes and Drug Oxidations documents the proceedings of symposium on microsomes and drug oxidations held at Bethesda, Maryland, 16-17 February 1968. The theme of the symposium centered on the morphology of the liver endoplasmic reticulum, the localization of enzyme systems, the mechanisms for regulating enzyme activity, and the mechanisms of enzyme action. The results of this symposium presented in this book illustrate the complexity of the enzyme systems under investigation and the multiplicity of the variables altering their function. It is hoped the information presented will serve as a stimulus to other investigators in the elucidation of these problems. The book contains 27 papers organized into four parts. The papers in Part I examine the morphological and biochemical characteristics of microsomes. Part II presents studies on electron transfer components. Part III examines alterations of microsomal enzymes while Part IV focuses on drugs and protein synthesis.

  • Toxicology and Occupational Medicine

    Proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine, Key Biscayne (Miami), Florida, October 22-25, 1978
    • 1st Edition
    • William B. Deichmann
    • English
    Toxicology and Occupational Medicine documents the proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine held in Key Biscayne (Miami), Florida, on 22-25 October 1978. The purpose of the conference was the presentation by delegates of research reports on subjects in the broad field of Toxicology and Occupational Medicine, followed by free discussions by all participants. This volume contains 47 papers and begins by tracing the history of the Inter-American Conferences. Subsequent chapters present papers on topics such as legal and scientific concerns over food safety; factors to consider to ensure the validity of the design of the experiment, the procedure for carrying it out, and the method of interpreting the results; and comparison of mutagenic, carcinogenic, and epidemiological data on known human carcinogens. Other papers cover the hidden carcinogen in the manufacture of isopropyl alcohol; developments in protecting workers from chemical hazards on the job; and safety evaluation of cosmetic ingredients.

  • The Scientific Basis of Drug Therapy in Psychiatry

    Proceedings of a Symposium Held at St. Bartholomew's Hospital, London
    • 1st Edition
    • John Marks + 1 more
    • English
    The Scientific Basis of Drug Therapy in Psychiatry is a collection of papers that covers the therapeutic effects and the mode of action of the various psychotropic drugs. The materials in the title are organized thematically based on the topic they tackle. The text first covers the articles on the basic concepts, such as anatomy and physiology of the emotions and their relation to psychoactive drugs, as well as the methods of assessment of psychological effects of drugs. The next three chapters cover the concerns with the psychotropic drugs that include clinical use, mode of actions, and pharmacology. The remaining paper talks about some of the considerations that need to be taken when administering psychotropic drugs. The book will be of great use to researchers and practitioners in behavioral science related disciplines, such as psychology, psychiatry, and neurology. Pharmacologists and medicinal chemists will also benefit from the text.

  • The Toxicology of Radioactive Substances

    Volume 3.59
    • 1st Edition
    • A. A. Letavet + 1 more
    • English
    The Toxicology of Radioactive Substances, Volume 3: Iron-59 deals with the experimental results of tests conducted at the Radiotoxicology Laboratory of the Institute of Occupational Hygiene and Disease, Academy of Medical Sciences, U.S.S.R. The book focuses on studies made on iron-59, which is widely used in science and technology, such as in the metal industry and in the research of hemoglobin metabolism in the bone marrow and red cells. Other studies show, however, that there is a long-term detrimental effect of intake of iron-59. The text then gives a brief outline of the physical, chemical, and biological properties of iron. Research also shows that the body's reaction to radioactive substances depends on how these are transmitted to the body and on their physicochemical properties. The effect of prolonged administration of radioactive iron on the electrical activity of the cerebral cortex of animals is analyzed, of which, possibly, the nervous system is most affected. The book notes also the changes in the red blood cells during chronic administration of iron-59 in small doses, wherein the hemoglobin levels increased temporarily. Studies of prolonged exposure to radioactive isotopes during pregnancy of the test animals show that there are significant changes in erythropoiesis, associated with iron deficiency. In another study, the prolonged internal administration of radioactive substances showed phasic changes in the height of electrocardiographic waves of the test animals. The text is suitable for physicists, nuclear scientists, doctors of toxicology, and researchers in nuclear medicine.

  • Opiate Receptors and the Neurochemical Correlates of Pain

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • Susanna Fürst
    • English
    Opiate Receptors and the Neurochemical Correlates of Pain, Volume V, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The congress offered a good opportunity to stimulate discussions and exchange of ideas between scientists from various countries who approach the problem of narcotics and pain mechanisms in different ways. The 27 contributions in this volume have enriched knowledge in this rapidly expanding field of pharmacology. This volume begins with a discussion of opiate receptors. The results suggest the interaction of various morphine-like drugs with different opiate receptor populations. The existence in nerve tissue of specific opiate receptors binding morphine and other opioids has led to the assumption of endogenous ligand for opiate receptors. One section of the present volume is devoted to enkephalins and endorphins, their structure-activity relationships, interactions with transmitter and other systems, their behavioral effects, and to factors controlling their release. Some other aspects of nociception; the pathways involved in the mode of action of different types of analgesics, e.g. narcotics and non-narcotics; and their relations to inflammation and active substances, such as prostaglandins and substance P, are discussed from various aspects.

  • Thorium-232 and Uranium-238

    The Toxicology of Radioactive Substances
    • 1st Edition
    • A. A. Letavet + 1 more
    • English
    The Toxicology of Radioactive Substances, Volume 4: Thorium-232 and Uranium-238 deals with the toxic properties of two radioactive elements, thorium-232 and uranium-238, as well as their soluble and insoluble compounds. Emphasis is placed on their biological effects and the late sequelae of their administration, especially in the case of insoluble compounds. Some of the results of laboratory studies on the acute and chronic effects of the very poorly soluble uranium compound U3O8 are presented. This volume is comprised of 12 chapters and opens with an overview of certain aspects of the toxicology of insoluble compounds of thorium-232 and uranium-238, followed by a discussion on the comparative toxicity of soluble and insoluble compounds of thorium-232. Subsequent chapters explore the absorption, distribution, and excretion of certain soluble compounds of natural thorium; the behavior of thorium dioxide in rats after intratracheal and intraperitoneal administration; the effect of thorium dioxide on the peripheral blood of rats; and photometric determination of low amounts of thorium in biological materials. Changes in the peripheral blood following chronic and acute poisoning with U308 are also considered. This book will be of interest to chemists and toxicologists.

  • Mode of Action, Metabolism and Toxicology

    Pesticide Chemistry: Human Welfare and the Environment
    • 1st Edition
    • S. Matsunaka + 2 more
    • English
    Pesticide Chemistry: Human Welfare and the Environment, Volume 3: Mode of Action, Metabolism and Toxicology covers the proceeding of the Fifth International Congress of Pesticide Chemistry. This book is organized into three parts that tackle relevant issues regarding the use of pesticide. The opening part tackles topics relevant to the biochemistry of pests and mode of action of pesticides, such as influence of chlorinated and parathyroid insecticide on cellular calcium regulatory mechanisms; behavioral and lethal actions of amidines on invertebrates; and insect chitin synthetase as biochemical probe for insecticidal compounds. The second part encompasses metabolism and degradation of pesticides and xenobiotics and includes topics on propesticides; selective toxicity conferred by activation; and comparative biochemistry of animal, plant, and microorganism oxidases. The last part covers the toxicology of pesticides and xenobiotics, including the role of biochemical studies in modern toxicological assessment of pesticides; neurophysiological and behavioral assessment of pesticide toxicity; and genetic toxicology applied to the assessment of mutagenic, carcinogenic, and teratogenic action of pesticides and related compounds. This book will be of great interest to chemists, biologists, botanists, and entomologists or professionals whose line of work involves the use of pesticides and who are concerned with pesticide side-effects to the users and the environment.

  • Toxicology

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • Y. Cohen
    • English
    Advances in Pharmacology and Therapeutics, Volume 9: Toxicology is a collection of papers that tackles advances in toxicological research in context of pharmacology. The text first covers reactive metabolites and their implications for toxicology. Next, the selection deals with the experimental and clinical correlations of behavioral toxicology. The text also tackles toxicology and pharmacology of topical application. The book will be of great use to researchers and practitioners of health related disciplines.

  • Polydrug Abuse

    The Results of a National Collaborative Study
    • 1st Edition
    • Donald R. Wesson + 2 more
    • English
    Polydrug Abuse: The Results of a National Collaborative Study reports on the findings of a national study of polydrug users, initiated and organized by the Special Action Office of Drug Abuse Prevention. This book provides a comprehensive demographic, sociological, psychological, and medical study of polydrug cases. The chapters in the text cover the varieties and classification of polydrug abusers; an estimation of the magnitude of polydrug abuse; certain central nervous system consequences to chronic drug use; and the impact of polydrug abuse on physicians and other deliverers of health care. Physicians, epidemiologists, drug enforcers, and government policy makers will find the book interesting.

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