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Elsevier

Books in Life sciences

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1st Edition
    • Chris Van Der Walle
    • English
    Interest in gene and cell therapies has increased dramatically following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access. Gene and Cell Therapies: Principles of Pharmaceutical Development provides insight to the key principles of emerging scientific and technical strategies to overcome these obstacles. How the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, autologous and allogeneic cell therapies, impacts their pharmaceutical development is outlined. The advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are related to the process and analytical developments that ensure their quality. The scope and style, along with included case studies, learning points and lecture slides, will allow the non-specialist to develop a foundational understanding, while the contemporary concepts discussed will urge further advancement of these exciting medicines.

  • The Immunology of Horses and Donkeys

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Horses and Donkeys offers a comprehensive overview of the immune systems of equids, bridging a critical gap by combining current research with foundational concepts and emphasizing both mechanisms and practical applications. The book covers immune development, disease resistance, vaccination, and immune disorders, supporting improved health management in horses and donkeys. Organized logically, it begins with the evolutionary history and domestication of equids and then explores immune ontogeny, innate and adaptive responses, and lymphoid tissue structure. Chapters detail the major histocompatibility complex, cytokine signaling, antigen-presenting cells, and mucosal immunity.Additional sections address the microbiota, vaccine strategies, and immune responses to bacterial, viral, and parasitic infections, providing a holistic view of equine immune health. Users will find content that advances understanding in immunology, biomedical research, and veterinary medicine, supporting the development of better diagnostics, vaccines, and therapies. The book's clear, thorough approach benefits both scientific discovery and clinical application, ultimately improving equine health and informing broader mammalian immunology studies.

  • Microneedle Technology

    Advances and Biomedical Applications
    • 1st Edition
    • Chuanbin Wu + 3 more
    • English
    Microneedle Technology: Advances and Biomedical Applications provides a detailed overview of advances in microneedle structure, materials, fabrication, and the strategies to improve drug delivery efficiency. In addition, it focuses on the application of microneedles for the treatment of diverse diseases, including diabetes, tumors, infectious disease, inflammatory diseases, skin infections, and wound healings. The book also summarize the application of microneedles for cosmetic purposes and biological monitoring and diagnosis.

  • The Evolution of Artificial Intelligence in Healthcare

    From Basic Methods to Clinical Practice
    • 1st Edition
    • Mario Cannataro
    • English
    The Evolution of Artificial Intelligence in Healthcare: From Basic Methods to Clinical Practice explores revolutionary technological advancements in the medical and healthcare realms due to generative AI and Deep Learning. This comprehensive guide not only explores cutting-edge technologies such as transformers and large language models for newcomers but also demystifies advanced applications like sequential decoding techniques and segmentation algorithms rarely explored in other literature. Sections cover foundational concepts and terminologies, explore deep learning and generative AI, provide AI's role in biomedical research, examine its integration into clinical practice, scrutinize its applications in public health, and discuss challenges and future prospects.This is an indispensable resource for healthcare professionals, scientists, researchers, students, and enthusiasts seeking to deepen their understanding of this rapidly evolving field.

  • Mitochondrial Genomics

    Insights into Dysfunction and Disease
    • 1st Edition
    • Aruna Pal + 1 more
    • English
    Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.

  • Biotic Interactions across Gradients and Scales

    • 1st Edition
    • Wesley Dáttilo + 1 more
    • English
    Biotic Interactions across Gradients and Scales provides a valuable exploration of the intricate connections of the web of life, including foundational ecological principles to current macroecological perspectives. The book examines the various dimensions of biotic interactions across spatiotemporal gradients in terrestrial and aquatic environments. Its integrated approach is crucial to understanding the potential responses of ecological networks to unprecedented stressors, including climate change, anthropogenic impacts, and loss of connectivity and functional redundancy. Written by renowned subject matter experts from the global North and South, this book introduces the concept of biotic interactions before delving into the physical factors influencing ecological networks.Central chapters describe the tools, methods, and history of study of biotic interactions. Latter chapters explore such networks across aquatic and terrestrial domains, before concluding chapters discuss disruptive stressors and open science opportunities for future research endeavors. Case studies, boxed elements, and end chapter review questions ensure student mastery of content.

  • Laser Polarization and Autofluorescence Imaging for Biomedical and Clinical Applications

    • 1st Edition
    • Alexander Ushenko
    • English
    Laser Polarization and Autofluorescence Imaging for Biomedical and Clinical Applications addresses the cutting-edge research area of laser and autofluorescence polarimetric visualization combined with sophisticated multi-algorithm digital analysis. The book’s content spans ten detailed sections, covering fundamental theories of Mueller-matrix polarimetry, azimuth-invariant mapping methods, advanced Fourier and wavelet transformations, singular analysis, laser-induced autofluorescence polarimetry, and biomedical system architectures. It culminates with clinical application examples demonstrating early diagnostics of malignancies, type 2 diabetes, albuminuria, cholelithiasis, septic conditions, and forensic determinations such as cause and time of death.This reference offers significant benefits to researchers, biomedical engineers, and medical data analysts by delivering a pioneering synthesis of the latest theoretical concepts and multifunctional digital imaging methods. It equips the audience with objective, highly sensitive digital markers essential for accurate, rapid preclinical diagnostics, thereby advancing precision medicine and evidence-based clinical practice in biomedical optics.

  • Applied Neuropsychology of Cerebrovascular Diseases

    A Practical Guide to Brain Arteries, Lesion Localization, and Rehabilitation Strategies
    • 1st Edition
    • Helmut Hildebrandt + 2 more
    • English
    Applied Neuropsychology of Cerebrovascular Diseases: A Practical Guide to Brain Arteries, Lesion Localization, and Rehabilitation Strategies addresses the critical intersection of vascular neurology and neuropsychological rehabilitation. The book explores the pathophysiology of stroke, emphasizing the importance of cerebrovascular anatomy and lesion localization in understanding cognitive deficits. It provides essential knowledge for clinicians involved in stroke assessment and treatment, highlighting the need for integration of neuroimaging interpretation into neuropsychological practice. Early sections offer foundational insights into cerebrovascular anatomy, stroke mechanisms, and their typical cognitive and emotional impairments.The second section equips clinicians with practical skills to independently interpret brain scans, utilizing tools like MRIcron to accurately localize lesions. The final section focuses on targeted rehabilitation strategies for common stroke syndromes, including neglect, aphasia, visual field deficits, and disorders of consciousness, all of which are supported by real-world clinical guidance and emerging neuromodulation techniques such as tDCS.

  • NEURO BASIC: Brain and Spine Illustrated Compendium – Anatomical Notebook

    • 1st Edition
    • Helbert de Oliveira Manduca Palmiero
    • English
    Neuro Basic: Brain and Spine Illustrated Compendium – Anatomical Notebook is a comprehensive, visually driven neuroanatomy reference that addresses the critical need for an accessible resource that bridges foundational anatomy with clinical applications. It fills the gap left by traditional texts that are either overly detailed or insufficiently practical, offering an integrated approach that emphasizes surgical relevance and visual clarity. Its content supports learners in understanding complex neuroanatomical relationships essential for diagnosis, surgical planning, and clinical decision-making, thereby enhancing their ability to interpret neuroimaging, perform neuroanatomical localization, and develop surgical strategies.The structured Table of Contents systematically guides the reader through the cranial vault, cerebral lobes, ventricular system, deep nuclei, brainstem, cerebellum, vascular anatomy, and spinal structures, including cervical, thoracic, and lumbar regions. Each chapter combines clear illustrations with concise descriptions, fostering a layered understanding from macrostructures to functional topography. Additional sections on neurofunctional topography, dermatomes, and myotomes facilitate clinical correlation, making this an indispensable tool for practical neuroanatomy.

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