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Elsevier

Academic Press

  • Formulation and Device Lifecycle Management of Biotherapeutics

    A Guidance for Researchers and Drug Developers
    • 1st Edition
    • Beate Bittner + 1 more
    • English
    Today, the pressure on healthcare costs and resources is increasing, and especially for biopharmaceuticals that require parenteral administration, the inherent complex and invasive dosing procedure adds to the demand for efficient medical management. In light of the COVID-19 pandemic the value of drug delivery technologies in enabling a flexible care setting is broadly recognized. In such a setting, patients and their caregivers can choose the place of drug administration based on individual preferences and capabilities. This includes not only dosing in the clinic but also supervised at-home dosing and self-administration for eligible patients. Formulation and Device Lifecycle Management of Biotherapeutics: A Guidance for Researchers and Drug Developers covers the various aspects of improving drug delivery of biological medicines with the ultimate goal to reduce dosing complexity associated with parenteral administration and, thus, enhance patient experience and drug administration-relat... healthcare capacity. The target audience are multidisciplinary researchers and drug developers in the pharmaceutical industry, biotech companies, and academia involved in formulation and device development. This includes pharmacology and medical experts in charge of generating nonclinical and clinical data to support approval of novel dosing regimens, and drug delivery scientists and engineers responsible for technical particulars of product optimizations. Moreover, professionals in market access and commercial functions are expected to benefit from the discussions about the impact of patient and healthcare provider needs and country-specific reimbursement models on realizing a truly convenient and cost and resource efficient drug delivery solution.

  • Intelligent Sensing and Communications for Internet of Everything

    • 1st Edition
    • Zhengyu Zhu + 2 more
    • English
    Intelligent Sensing and Communications for Internet of Everything introduces three application scenarios of enhanced mobile broadband (eMBB), large-scale machine connection (mMTC) and ultra reliable low latency communication (URLLC). A new communication model, namely backscatter communication (BackCom), intelligent reflector surface (IRS) and unmanned aerial vehicle (UAV) technology in Internet of Everything (IoE), is described in detail. Also focusing on millimeter wave, the book discusses the potential application of terahertz 6G network spectrum in the Internet of Things (IoT). Finally, the applications of IoE network in big data, artificial intelligence (AI) technology and fog/edge computing technology are proposed.

  • Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

    • 1st Edition
    • Volume 18
    • English
    Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormone... immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field.

  • Advances in Protein Molecular and Structural Biology Methods

    • 1st Edition
    • Timir Tripathi + 1 more
    • English
    Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application.

  • Advanced Data Mining Tools and Methods for Social Computing

    • 1st Edition
    • Sourav De + 3 more
    • English
    Advanced Data Mining Tools and Methods for Social Computing explores advances in the latest data mining tools, methods, algorithms and the architectures being developed specifically for social computing and social network analysis. The book reviews major emerging trends in technology that are supporting current advancements in social networks, including data mining techniques and tools. It also aims to highlight the advancement of conventional approaches in the field of social networking. Chapter coverage includes reviews of novel techniques and state-of-the-art advances in the area of data mining, machine learning, soft computing techniques, and their applications in the field of social network analysis.

  • Advances in Agronomy

    • 1st Edition
    • Volume 171
    • Donald L. Sparks
    • English
    Advances in Agronomy, Volume 171, the latest release in this leading reference, contains a variety of updates and new advances in the field, including updates on Elevated CO2 in Semi-arid Cropping Systems: A Synthesis of Research from the Australian Grains Free Air CO2 Enrichment (AGFACE) Research Program, Simultaneous Effects of Legume Cultivation on Carbon and Nitrogen Accumulation in Soil, Growing Small Grains Organically in the Semiarid West: A Review of Markets and Management Practices to Optimize Productivity and Sustainability, Principles and Applications of Topography in Precision Agriculture, Retention of Heavy Metals by Dredged Sediments and their Management Following Land Application, and more. Other chapters focus on Genetic Diversity for Developing Climate-resilient Wheats to Achieve Food Security Goals and A Century of Subclover: Lessons for Sustainable Intensification from a Historical Review of Innovations in Subterranean Clover Seed Production.

  • Artificial Intelligence for Healthcare Applications and Management

    • 1st Edition
    • Boris Galitsky + 1 more
    • English
    Artificial Intelligence for Healthcare Applications and Management introduces application domains of various AI algorithms across healthcare management. Instead of discussing AI first and then exploring its applications in healthcare afterward, the authors attack the problems in context directly, in order to accelerate the path of an interested reader toward building industrial-strength healthcare applications. Readers will be introduced to a wide spectrum of AI applications supporting all stages of patient flow in a healthcare facility. The authors explain how AI supports patients throughout a healthcare facility, including diagnosis and treatment recommendations needed to get patients from the point of admission to the point of discharge while maintaining quality, patient safety, and patient/provider satisfaction. AI methods are expected to decrease the burden on physicians, improve the quality of patient care, and decrease overall treatment costs. Current conditions affected by COVID-19 pose new challenges for healthcare management and learning how to apply AI will be important for a broad spectrum of students and mature professionals working in medical informatics. This book focuses on predictive analytics, health text processing, data aggregation, management of patients, and other fields which have all turned out to be bottlenecks for the efficient management of coronavirus patients.

  • Hormones

    • 4th Edition
    • Gerald Litwack
    • English
    Hormones, Fourth Edition provides a report on the field of human hormones viewed in light of our current understanding of cellular and subcellular architecture, along with the molecular details of their modes of action. Comprehensive information about hormone action on canonical and non-canonical signaling pathways at cellular and subcellular level and effects on architecture and function of organ systems are discussed. All chapters in this new edition have been completely updated to cover advances in endocrinology research, which has expanded significantly in the last few years. Vast coverage of hormones not previously covered and newly discovered aspects of hormone action are also included. This new fourth edition is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for health professionals, clinicians and researchers in the field of endocrinology, metabolism and biochemistry.

  • Medical Device Regulations

    A Complete Guide
    • 1st Edition
    • Aakash Deep
    • English
    Medical Device Regulations: A Complete Guide describes a brief review of various regulatory bodies of major developed and developing countries around the world. The book covers the registration procedures of medical devices for pharmaceutical regulatory organizations. Sections provide guidance on dealing with the ethical considerations of medical device development, compliance with patient confidentiality using information from medical devices, the interoperability between, and among devices outside of healthcare, and the dynamics of implementation of new devices to ensure patient safety. The author brings forth relevant issues, challenges and demonstrates how management can foster increased clinical and non-clinical relations to enhance patient outcomes and the bottom-line by demystifying the regulatory impact on operational requirements.

  • Understanding Cancer

    From Basics to Therapeutics
    • 1st Edition
    • Buddhi Prakash Jain + 1 more
    • English
    Understanding Cancer: From Basics to Therapeutics presents both basic concepts and research prospects in the field of cancer biology. This book summarizes the fundamental aspects of cancer and presents a detailed description of molecular aspects as well as treatment and therapeutics for patients. The book is divided into three parts: the first part deals with the basics of cancer, including etiology and medical diagnosis; the second part explores the molecular mechanisms associated with cancer, focusing on cell cycle and apoptosis, cell metabolism, gene regulation, epigenetics, and stem cells; and the third part is dedicated to therapeutics, discussing chemo and radiotherapies, gene, hormone, herbal, and immunotherapies. It is a valuable resource for cancer researchers, oncologists, graduate students, and biomedical researchers who need to understand the fundamental topics related to cancer to apply to their research work or clinical setting.

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