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  • Microplastics and Nanoplastics in Human Health

    Pathways of Exposure and Toxicological Impacts
    • 1st Edition
    • Mohammad Hadi Dehghani + 2 more
    • English
    Microplastics and Nanoplastics in Human Health: Pathways of Exposure and Toxicological Impacts is a comprehensive exploration on how microscopic plastic particles affect human health. While much attention has been paid to environmental impacts, this book focuses on the biological consequences of human exposure. It traces the journey of plastics from global production to their breakdown into micro- and nanoplastics, detailing how they enter the body through food, water, air, and skin contact. The book investigates toxicological mechanisms—such as inflammation, oxidative stress, and endocrine disruption—linking plastic exposure to chronic diseases.In addition, it examines how these particles and their chemical additives may harm key systems, including respiratory, digestive, nervous, endocrine, reproductive, and immune systems. Real-world case studies highlight exposure risks across different populations and environments. By integrating human biomonitoring data with advanced risk assessment frameworks, the book offers a scientific foundation for health professionals, researchers, and policymakers.

  • Cell Free Synthesis of Biologics

    A Comprehensive Guide
    • 1st Edition
    • Sarfaraz Niazi
    • English
    Cell Free Synthesis of Biologics: A Comprehensive Guide addresses the need for efficient production methods in biopharmaceutical manufacturing. As the demand for biologics continues to rise, traditional cell-based production systems often fall short due to high costs and complexity. This book offers a detailed exploration of cell-free protein synthesis (CFPS), providing researchers and professionals with the latest methodologies, best practices, and troubleshooting strategies necessary for successful implementation. The content is structured into comprehensive chapters that cover the historical development, technical foundations, optimization strategies, advanced technologies, and the regulatory landscape surrounding CFPS.Each section is designed to guide users through the complexities of establishing and scaling up cell-free systems, ensuring a clear understanding of the processes involved and the potential applications in therapeutic development, diagnostics, and industrial biotechnology. This book provides pharmaceutical scientists and pharma manufacturing professionals with practical insights and innovative strategies to enhance efficiency and reduce costs in biopharmaceutical production.

  • Knowledge Graphs and Large Language Models

    Current Approaches, Challenges, and Future Directions
    • 1st Edition
    • Sanju Tiwari + 3 more
    • English
    Knowledge Graphs and Large Language Models: Current Approaches, Challenges, and Future Directions explores the cutting-edge fusion of two powerful artificial intelligence technologies: Large Language Models (LLMs) and Knowledge Graphs (KGs). The book is structured to provide a comprehensive understanding of this emerging field. Chapters introduce the synergy between LLMs and KGs, delve into the capabilities and challenges of LLMs, focus on the structure, function, and significance of KGs, present a conceptual framework for bridging LLMs and KGs, discuss techniques for their integration, explore how LLMs can enhance KGs and vice versa, and showcase applications of LLM-KG synergy across various domains.Final sections addresses ethical, social, and technical challenges and future innovations. The book concludes by summarizing key insights and advancements in intelligent systems. This is an essential resource for graduate students, researchers, and professionals in computer science. It offers valuable insights for adopting LLMs, KGs, and their advanced applications in research and product development. By bridging the gap between these technologies, this book equips readers with the knowledge to drive innovation and enhance the capabilities of intelligent systems.

  • Healing Botanicals

    From Tradition to Therapeutics
    • 1st Edition
    • Awanish Kumar + 4 more
    • English
    Healing Botanicals: From Tradition to Therapeutics explores the connection between traditional herbal wisdom and modern medical science, examining herbaceuticals—plant... compounds with therapeutic potential—through the lens of clinical evidence, pharmacology, and global healthcare practices. Organized into five parts, the book begins by tracing the evolution of herbal medicine and delving into the phytochemical and pharmacological foundations of healing botanicals. Subsequent sections focus on botanicals for stress, immunity, digestion, chronic pain, mental health, and cardiovascular support, highlighting their applications in disease management.Special emphasis is placed on the integration of adaptogens, immune-boosting herbs, and neuroprotective botanicals in contemporary therapeutic strategies. In addition to therapeutic uses, the book addresses critical concerns such as safety, clinical validation, regulatory frameworks, and quality control. It concludes by forecasting the future of herbal medicine, exploring innovations, global trends, and the potential of plant-based therapies in preventive and personalized healthcare.

  • Cellular Senescence and Cardiac Aging

    Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases
    • 1st Edition
    • Gaurav Gupta + 4 more
    • English
    Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.

  • Integrating Artificial Intelligence with Virtual Screening

    A New Era in Drug Discovery
    • 1st Edition
    • Vivek Asati + 1 more
    • English
    Integrating Artificial Intelligence with Virtual Screening: A New Era in Drug Discovery addresses the evolving landscape of drug discovery by combining traditional virtual screening with cutting-edge artificial intelligence technologies. This volume offers an interdisciplinary guide to AI-driven ligand and structure-based screening methods, including machine learning, deep learning, and generative models, thus enabling faster and more accurate identification of drug candidates. It covers mathematical models, computational workflows, and optimization strategies such as Pareto-based and physics-based approaches.Sections also discuss challenges in navigating ultra-large chemical libraries and present practical case studies that demonstrate real-world applications. Edited by leading researchers, the book provides authoritative insights suited for graduate students, researchers, and industry professionals. Users will be empowered by the latest tools and knowledge to innovate drug discovery pipelines and support the development of precision medicines and foster advancements in pharmaceutical sciences.

  • Medical and Health Genomics of South Asia

    • 1st Edition
    • Dhavendra Kumar + 1 more
    • English
    Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region.Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

  • Nanophytomedicine

    Harnessing Phytochemicals for Advanced Therapeutics
    • 1st Edition
    • Ali Zarrabi + 2 more
    • English
    Nanophytomedicine: Harnessing Phytochemicals for Advanced Therapeutics explores the integration of phytochemicals and nanotechnology to develop advanced therapeutic solutions. The book offers an extensive overview of phytochemicals, explaining their sources, extraction methods, classifications, and applications in medicine. This emerging field aims to utilize the natural properties of phytochemicals to create innovative treatments for various diseases, with a particular focus on hard-to-treat conditions such as cancer. By combining plant-derived compounds with nanomaterials, researchers are unlocking new potential in precision medicine, seeking to enhance the efficacy of treatments while minimizing side effects and improving patient outcomes.In 18 comprehensive chapters, the book delves into the therapeutic properties of phytochemicals, such as their antioxidant, antifungal, and anti-inflammatory effects. It highlights the role of these compounds in combating diseases including cancer, neurological disorders, diabetes, and cardiovascular diseases. The use of nano drug delivery systems is emphasized, showcasing how these technologies can improve the delivery and effectiveness of phytochemicals.

  • Metabolic Memory

    Past, Present and Future Implications
    • 1st Edition
    • Jeena Gupta
    • English
    Metabolic Memory: Past, Present and Future Implications delves into the emerging concept of metabolic memory, exploring how our body's metabolic processes retain a 'memory' of past experiences and how this impacts our current and future health. Drawing on the latest scientific research this book aims to bridge the gap between complex scientific concepts and their practical implications for everyday health and wellness. Metabolic memory has profound implications for understanding chronic diseases, particularly diabetes, cardiovascular diseases, and obesity. Despite its significance, there is a lack of comprehensive resource that make this information accessible to both professionals and the general public. This book fills that gap, providing a detailed yet understandable exploration of how past metabolic states influence present and future health outcomes.

  • Environmental Microbiology

    • 4th Edition
    • Ian Pepper + 3 more
    • English
    Environmental Microbiology, Fourth Edition is the revised edition of a key, foundational text for the field of environmental microbiology which hits all the pillars of the field and takes into account the tremendous advances in environmental microbiology over past decade. It provides comprehensive information on traditional methodologies utilized to study environmental microbes, as well as state-of-the-art technologies. Emphasis is placed on molecular and bio-informatic approaches to the study of environmental microbes, including nucleic acid and ‘omic methodologies. The book is divided into seven parts that stretch across microbiology concepts, microbial environments, microbial methods and technologies, microbial transport, biogeochemistry, and bioremediation, water and foodborne pathogens, wastewater treatment and distribution, and urban microbiology. 1) “Environmental Microbiology” is the study of microbes within all habitats, and their beneficial and detrimental impacts on human health and welfare. This book illustrates the significance of environmental microbes in our daily lives in terms of not only the overall health of the planet, but also: what infects us; what heals us; what we drink; what we eat; and what we breathe.

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