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Elsevier

Academic Press

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 19
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 19 analyzes the advances in the general area of cellular regulation. This book discusses the evidence indicating that synthesis of the histidine enzymes is regulated and drugs affecting ribonucleotide reductase. The analogy principle in comparative biochemistry of allosteric regulation of metabolism, steady-state model of glucose metabolism in adipose tissue, and sensitivity of enzyme activity to changing ion concentrations are also elaborated. This publication likewise covers the cAMP-dependent protein kinases of nervous tissue and amino acid sequences of IGF I and II. This volume is a good reference for biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.

  • Developments in Statistics

    • 1st Edition
    • Volume 4
    • Paruchuri R. Krishnaiah
    • English
    Developments in Statistics, Volume 4 reviews developments in the theory and applications of statistics, covering topics such as time series, identifiability and model selection, and missing data. The application of structured exploratory data analysis to human genetics, specifically, the mode of inheritance, is also considered. Comprised of four chapters, this volume begins with an introduction to spectrum parameter estimation in time series analysis, restricting the discussion to the simplest univariate (that is, scalar) real-valued time series X(t). An accurate formulation of the general problem is presented. The accuracy of different consistent estimates obtained for large but fixed values of T (maximum likelihood estimates, Whittle's estimates, and simplified asymptotically efficient estimates) is also compared. The next chapter deals with identifiability and modeling in econometrics, focusing on the theoretical framework relating realization theory, identification, and parametrization. The realization theory is illustrated on various levels of generality by means of examples related to econometrics, along with some advanced applications of system theory. The book also examines inference on parameters of multivariate normal populations when some data are missing before concluding with an evaluation of structured exploratory data as applied to the study of the mode of inheritance. This monograph will be of interest to students and practitioners of statistics.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 6
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 6 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into eight chapters, this volume begins with an overview of the well-defined stages of sporulation that can be correlated with the appearance of several enzymes, ultrastructures, and chemical components associated with the developing spore. This text then examines the regulatory properties of G6PD from various sources, with emphasis to those cells in which these properties may operate in vivo in the control of carbohydrate metabolism. Other chapters consider the various methods for analyzing biochemical systems. The final chapter deals with kinetic cooperativity, which is the basis of the flip-flop mechanism. This book is a valuable resource for biochemists, biologists, and research workers.

  • Horizons of Bioenergetics

    Proceedings of a Symposium held at Bloomington, Indiana October 12-15, 1970
    • 1st Edition
    • Anthony San Pietro + 1 more
    • English
    Horizons of Bioenergetics provides information pertinent to the fundamental aspects of bioenergetics. This book covers a variety of topics, including oxidative phosphorylation, energy conservation, ATP formation, metabolic regulation, glycolysis, and photosynthesis efficiency. Organized into five sessions encompassing 23 chapters, this book begins with an overview of the major landmarks in biochemical evolution that are most relevant to the discussion on bioenergetics. This text then reviews the knowledge about ATP generation by substrate level phosphorylation by anaerobic bacteria that ferment organic compounds. Other chapters consider the resolution and reconstitution of oxidative phosphorylation. This book discusses as well another energy-requiring activity associated with electron transport in mitochondria that may take primacy over oxidative phosphorylation. The final chapter deals with the possibility that conformational change can induce major shifts in electro-chemical potential and provide a mechanism for energy storage and conversion. This book is a valuable resource for biochemists, scientists, and research workers.

  • Experimental Manipulation of Gene Expression

    • 1st Edition
    • Masayori Inouye
    • English
    Experimental Manipulation of Gene Expression discusses a wide range of host systems in which to clone and express a gene of interest. The aims are for readers to quickly learn the versatility of the systems and obtain an overview of the technology involved in the manipulation of gene expression. Furthermore, it is hoped that the reader will learn enough from the various approaches to be able to develop systems and to arrange for a gene of particular interest to express in a particular system. The book opens with a chapter on the design and construction of a plasmid vector system used to achieve high-level expression of a particular phage regulatory protein normally found in minute amounts in a phage-infected bacterial cell. This is followed by separate chapters on topics such as high-level expression vectors that utilize efficient Escherichia coli lipoprotein promoter as well as various other portions of the lipoprotein gene Ipp; DNA cloning systems for streptomycetes; and the design and application of vectors for high-level, inducible synthesis of the product of a cloned gene in yeast.

  • Human Performance Models for Computer-Aided Engineering

    • 1st Edition
    • Jerome I. Elkind + 2 more
    • English
    Human Performance Models for Computer-Aided Engineering is a collection of papers that deals with the relationship between scientific theories of human performance and practical engineering. This collection describes the emergence of a scientific engineering paradigm that uses computational theories in computational design aids. This book also considers computational human factors such as human performance models and their application in computer-based engineering designs. This text then presents applications of these models to some helicopter flight problems. This book also explains the four requirements in programming a computer-based model of the sensory performance of a pilot as 1) prediction capability; 2) measurement capability; 3) provision of compatible computer algorithms; and 4) image driven. This collection also describes cognitive structures—aspects of the human information processing system. This text then discusses resource management and time-sharing issues that is related to competition of scarce resources, which can be predictive of the quality of information processing. This book also describes other modeling scenarios such as those predicting human errors, decision making, and shape modeling. This text can prove valuable for computer programmers, engineers, physicists, and research scientists dealing with psychophysics.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 12
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 12 focuses on the binding of polypeptide hormones to the specific receptor sites on the cellular membrane. This book consists of six chapters. Chapter 1 describes how several polypeptide regulators, hormones, and growth factors act through very similar mechanisms. The second messenger roles of cAMP and cGMP in the regulation of various protein kinases are dealt with in Chapter 2. Chapter 3 discusses the experimental conditions employed in studying the characteristics of regulatory enzymes in vitro and in vivo, while Chapter 4 elaborates the intracellular compartmentation of enzymes, cofactors, and metabolic intermediates of glycolysis in various tissues from different organisms. The biochemical mechanisms that underlie the induction of enzymes in catabolic pathways are considered in Chapter 5. The last chapter is devoted to the role of T4 phage-induced covalent modification reactions in the transcriptional control of DNA-dependent RNA-polymerase in E. coli. This volume is suitable for biologists and researchers concerned with the basic mechanisms involved in the regulation of diverse cellular activities.

  • Speech and Language

    Advances in Basic Research and Practice
    • 1st Edition
    • Volume 11
    • Norman J. Lass
    • English
    Speech and Language: Advances in Basic Research and Practice, Volume 11 contains articles that discuss a wide range of topics on speech and language processes and pathologies. This volume is comprised of six contributions on a wide variety of topics on speech and language. The book begins with an examination of approaches to aphasia diagnostics from both a medical and nonmedical perspective. Subsequent chapters cover topics on acoustic-phonetic descriptions of speech production in speakers with cleft palate and other velopharyngeal disorders; the role of infant vocalizations as they relate to subsequent speech and language development; pitch phenomena and applications in electrolarynx speech; and practical applications of neuroanatomy. The final chapter presents the employment of studies of temporal coordination to understand the development of motor control in speech and to provide a basis for testing theories on the development of speech as a motor skill. Linguists, speech pathologists, and researchers on language development will find the book very insightful and informative.

  • Modulation by Covalent Modification

    • 1st Edition
    • Volume 27
    • Shmuel Shaltiel + 1 more
    • English
    Current Topics in Cellular Regulation: Volume 27, Modulation by Covalent Modification is a compendium of papers dealing with the coordination, function, or control of cellular metabolism, particularly on modulation by covalent modification. One paper reviews the cyclic cascade model in metabolic regulation that shows the model's applicability to all covalent interconvertible enzyme systems, such as those modified by phosphorylation, ADP-ribosylation, carboxymethylation, acetylation, and sulfation. Another paper discusses the hypothesis that smooth muscle contraction is regulated by a calcium-dependent phosphorylation of the myosin molecule. Studies made by Sellers and Pato suggest that a phosphatase isolated from turkey gizzard muscle (known as smooth muscle phosphatase IV) can be related to an in vivo myosin phosphatase as the phosphatase IV binds well to both myosin and thiophosphorylated myosin. Other papers describe in situ regulation studies of Excherichia coli glutamine synthethase, the posttranslational processing of the insulin proreceptor, and selenium in cellular metabolism. The compendium is suitable for biochemists, microbiologists, and academicians whose works involve research in cell biology.

  • Advances in Steroid Biochemistry and Pharmacology

    • 1st Edition
    • M. H. Briggs + 1 more
    • English
    Advances in Steroid Biochemistry and Pharmacology, Volume 4 provides information pertinent to the fundamental aspects of steroid biochemistry and pharmacology. This book covers a variety of topics, including cellular biochemistry, pituitary hormones, corticosteroids, and steroid hormones. Organized into seven chapters, this volume begins with an overview of the potential effects of steroids on cellular biochemistry. This text then examines the development of sleep-monitoring methods, together with methods of plasma sampling that enable very frequent specimen to be taken without disturbing the subject. Other chapters consider the usefulness of sleep-related growth hormone release in diagnosis in both children and adult. This book discusses as well the versatile effect of corticosteroids on the cellular components of the connective tissue. The final chapter deals with the functioning of the adrenal cortex and its control by adrenocorticotropic hormone (ACTH). This book is a valuable resource for biochemists, histochemists, biologists, pharmacologists, clinicians, and experimental endocrinologists.

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