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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Biomarkers in Toxicology

    • 1st Edition
    • Ramesh C. Gupta
    • English
    Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields.

  • Toxicogenomics-Based Cellular Models

    Alternatives to Animal Testing for Safety Assessment
    • 1st Edition
    • Jos Kleinjans
    • English
    Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

  • Handbook of Nanosafety

    Measurement, Exposure and Toxicology
    • 1st Edition
    • Ulla Vogel + 5 more
    • English
    Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment.

  • Electrocardiography of Laboratory Animals

    • 1st Edition
    • Jeffrey W. Richig + 1 more
    • English
    Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.

  • Drugs and Enzymes

    Proceedings of The Second International Pharmacological Meeting, Vol. 4
    • 1st Edition
    • Bernard B. Brodie + 1 more
    • English
    Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

  • Man and Biologically Active Substances

    The Effect of Drugs, Diet and Pollution on Health
    • 1st Edition
    • I. I. Brekhman
    • English
    Man and Biologically Active Substances: The Effect of Drugs, Diet and Pollution on Health presents an introduction to the pharmacology of health. This book describes the medicinal substances taken by a healthy individual for specific purposes in health maintenance. Organized into four chapters, this book begins with an overview of the doctrine of health and the doctrine of the nature and treatment of illness. This text then examines the important tasks of pharmacosanation in the utilization of biologically active substances that are useful to human activity and the elimination of those that are harmful. Other chapters consider some of the more significant products used by everyone or those special pharmacosanation substances that have been widely utilized as useful food products. This book discusses as well the usefulness of several kinds of plant materials used as medicines. The final chapter deals with the science of remedies for treating human illnesses. This book is a valuable resource for nutritionists and pharmacologists.

  • Poulsson's Text-Book of Pharmacology and Therapeutics

    • 1st Edition
    • Stanley Alstead
    • English
    Poulsson’s Text-Book of Pharmacology and Therapeutics, Second English Edition covers the considerable progress in understanding the basic principles, applications, and classifications of drugs and other organic compounds of therapeutic interest. This text is divided into six chapters, each dealing with a specific classification of drugs. The first chapter describes the so-called protoplasmic poisons, which are organic substances that are characterized by their specific effects after absorption on the nervous and muscular systems, while local effects are altogether absent or insignificant. The second chapter examines the organic remedies that principally act locally, such as at the point of application, while the action after absorption is unimportant or is not utilized in medicine. The third and fourth chapters explore the main groups containing the inorganic bodies. These chapters demonstrate that the inorganic compounds differ from the organic, whose activity is due to the unchanged entire molecules, and they are subjected to dissociation. The fifth chapter considers the digestive ferments and foodstuffs, while the sixth chapter is concerned with antitoxins and bacterial products. This book will be of value to pharmacologists, pharmacists, researchers, and pharmacology and pharmacy students.

  • An Introduction to Mechanisms in Pharmacology and Therapeutics

    • 1st Edition
    • Howard Rogers + 1 more
    • English
    An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.

  • Epidemiology in Country Practice

    • 1st Edition
    • William Norman Pickles
    • English
    Epidemiology in Country Practice presents the development of the catarrhal jaundice and myalgia. It discusses the epidemiological and clinical observations of country doctors. It addresses the conditions of life of a country doctor. Some of the topics covered in the book are the appeal to improved medical research; methods of communicating medical research; techniques in acquisition of clinical data; types of diseases of the people living in the country; description of influenza, measles, scarlet fever, whooping-cough, and mumps; and diagnosis and behavior of chicken-pox and shingles. The description of sonne dysentery is fully covered. An in-depth account of the diagnosis, symptoms, and treatment of undulant fever are provided. The characteristic mononucleosis of glandular fever is completely presented. A chapter is devoted to the classification and description of different skin conditions. Another section is focus on the diagnosis of malignant disease. The book can provide useful information to doctors, students, and researchers.

  • Symposium on Clinical Pharmacology

    Biochemical Pharmacology
    • 1st Edition
    • William A. Creasey + 2 more
    • English
    Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

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