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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • The Psychopharmacology of Hallucinogens

    • 1st Edition
    • Richard C. Stillman + 1 more
    • English
    The Psychopharmacology of Hallucinogens focuses on the properties, compositions, functions, transformations, and reactions of hallucinogens. The selection first offers information on the biosynthesis and action of hallucinogens in mammals; role of biogenic amines in the actions of monomethoxy-amphetam... and molecular mechanism of action of hallucinogens. The book then takes a look at the molecular determinants for interaction with the LSD receptor, including biological studies, molecular reactivity, and summation of the molecular polarization complexes. The text examines the progress on the development of a receptor model for hallucinogenic amphetamines; characterization of psychotomimetics; physical identification of hallucinogenic compounds; and aspects of the pharmacology of phencyclidine. The book also underscores the effects of LSD, mescaline, and DMT, including effects on humans, proposed model, and effects of monoamine manipulations. The text also presents analysis of hallucinogens by Pavlovian conditioning, behavioral measures of hallucinogenic behavior, and drug model of hallucinosis. The selection is a dependable reference for readers interested in the study of hallucinogens.

  • Natural Toxins

    Characterization, Pharmacology and Therapeutics
    • 1st Edition
    • C.L. Ownby + 1 more
    • English
    The 9th World Congress on Animal, Plant and Microbial Toxins was sponsored by the International Society on Toxinology which recently celebrated its 25th anniversary. The Society was organized to promote research into all aspects of natural toxins, and to help with the dissemination of knowledge. This book presents the most recent information on natural toxins from animal, plant and microbial origins and describes the state of research and clinical studies in the field. The material included is illustrated, referenced and fully indexed.

  • In Vitro Biological Systems

    Methods in Toxicology, Vol. 1
    • 1st Edition
    • Charles A. Tyson + 1 more
    • English
    Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. The text also describes liver slices; liver hepatocytes; other liver cell systems; proximal tubule fragments; kidney cell culture; reproductive and developmental systems; immune system; and skin. Pharmacologists, toxicologists, cell biologists, physiologists, immunotoxicologists, and molecular toxicologists will find the book invaluable.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 6
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume VI covers practical approaches to the development of bioactive compounds, with focus on antiradiation agents, organ-imaging radiopharmaceuticals... X-ray contrast media, proteinase inhibitors, and pesticide formulations. The book discusses the chemical routes available for the synthesis of diphenhydramine derivatives, the biological activities, the relationships between structure and activity, and the phase of manipulation in the design of diphenhydramine derivatives. The text also describes the design of antiradiation agents, organ-imaging radiopharmaceuticals... and X-ray contrast media, as well as the rational approach to proteinase inhibitors. The chemical and physical methods of formulation of agricultural pesticides are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design and manufacture will find the book invaluable.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 2
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of cholinesterases. The text also describes the design of reactivators for irreversibly blocked acetylcholinesterase... drug design based on the inhibition of protein synthesis in the context of susceptible enzymic reactions; as well as the role of enzymes and their synthesis as a target for antibiotic action. The rational design of antiviral agents; the design of penicillin; the design of peptide hormone analogs; as well as the advances in the design of diuretics are also considered. The book further tackles the design of biologically active steroids; the rational elements in the development of superior neuromuscular blocking agents; and the design of tumor-inhibitory alkylating drugs. Pharmacologists, chemists, and people involved in drug design will find the book invaluable.

  • Essays in Toxicology

    Volume 6
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 6 approaches toxicology by very different routes; two essays with materials (plastics and tobacco alkaloids), one deals with the effects of abnormal pressure, one considers the biochemistry of the lung, and one discusses poison control centers and other mechanisms for limiting the injury done by toxic materials. The book presents essays on the topological problems and untoward effects from plastic devices used in medical applications; the metabolism of tobacco alkaloids; and poisons control center. The text also includes essays on the toxicology of hypobaric and hyperbaric environments; as well as the exploitable biochemical approaches for the evaluation of toxic lung damage. Biochemists, physical chemists, neurophysiologists, epidemiologists, and social scientists will find the book invaluable.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 5
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume V covers the fundamental approaches to the development of bioactive compounds. The book discusses the utilization of operational schemes for analog synthesis in drug design; the design of enzyme inhibitors (transition state analogs); and the significance of structure-absorption... relationships for drug design. The text describes the role of charge-transfer processes in the action of bioactive materials, as well as the approaches to the rational combination of antimetabolites for cancer chemotherapy. The physicochemical, quantum chemical, and other theoretical techniques for the understanding of the mechanism of action of central nervous system (CNS) agents, such as psychoactive drugs, narcotics, and narcotic antagonists and anesthetics, are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.

  • Mitochondrial Dysfunction

    Methods in Toxicology, Vol. 2
    • 1st Edition
    • Lawrence H. Lash + 1 more
    • English
    Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

  • Biological and Environmental Aspects of Chromium

    • 1st Edition
    • Volume 5
    • S. Langård
    • English
    Biological and Environmental Aspects of Chromium focuses on the biological and environmental aspects of chromium and its compounds, with emphasis on the most important aspects of their toxicology and physiology. Topics covered range from the production and occupational exposure of chromium compounds to the presence of chromium in air, soil, and natural waters. The applications of chromium in cell biology and medicine are also discussed. Comprised of 11 chapters, this volume begins with an overview of the toxic and carcinogenic effects of chromium and chromium compounds, followed by a discussion on the production and occupational exposure of chromium compounds. The reader is then introduced to the more common analytical methods used in the determination of chromium in environmental and biological samples. Subsequent chapters explore the nutritional role of chromium; absorption, transport, and excretion of chromium in humans and animals; mutagenic and cytogenetic effects of chromium compounds; and organ toxicity of chromium in animals. The carcinogenic effects of chromium, including its effects on the skin, are also considered. This monograph will be of interest to students, practitioners, and researchers in the fields of biology, physiology, and chemistry, as well as those with an objective interest in the ways in which chromium and its compounds act in biological materials and in the human environment.

  • Advances in Drug Research

    Volume 12
    • 1st Edition
    • N. J. Harper + 1 more
    • English
    Advances in Drug Research, Volume 12 covers articles on advances in drug research. The book presents articles on cyclic nucleotides as targets for drug design; the opposing regulatory roles of cyclic nucleotides in the heart; and the integrated control of trematode diseases. The text also includes articles about the chemical and biological studies on indomethacin, sulindac and their analogs; as well as the pharmacokinetics, pharmacodynamics, toxicity, and the effects of bromocriptine. Toxicologists, pharmacologists, physicians, and drug researchers will find the book invaluable.

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