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  • Inflammation and Cancer

    Mechanisms, Diagnosis, and Therapeutic Strategies
    • 1st Edition
    • Anoop Kumar + 4 more
    • English
    Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.

  • Cybersecurity for Healthcare Systems in the Internet of Medical Things Era

    • 1st Edition
    • Janmenjoy Nayak + 2 more
    • English
    Cybersecurity for Healthcare Systems in the Internet of Medical Things Era is driven by the imperative to address the intricate convergence of healthcare, technology, and security. In response to the burgeoning challenges presented by the Internet of Medical Things (IoMT), this book is designed to be an indispensable resource for computer systems experts, healthcare staff, and executives. It goes beyond the surface, offering strategic insights and actionable strategies that encompass not only the IoMT landscape but also the intersection of artificial intelligence, signal processing, and cyber security. Cybersecurity for Healthcare Systems in the IoMT Era serves as a problem-solving compass for a diverse readership in the healthcare landscape. For healthcare professionals and IT leaders, the book untangles the complexities of integrating and securing Internet of Medical Things (IoMT) devices, offering a roadmap for understanding and navigating this rapidly evolving terrain. Biomedical engineers, burdened with strategic and everyday decisions, find in this book strategic insights and actionable strategies, empowering them to make informed choices amidst the ever-changing challenges posed by technology and cybersecurity threats. The authors present a comprehensive guide that not only elucidates the challenges and opportunities presented by IoMT but also explores how the synergy of AI and signal processing can elevate healthcare systems. This integration is crucial in deciphering the intricate nuances of medical data, enhancing diagnostics, and fortifying the security of interconnected healthcare networks.

  • Non-Invasive Brain Stimulation (NIBS) and Physiotherapy

    Non-Pharmacological Interventions for Neurological and Neuropsychiatric Disorders
    • 1st Edition
    • Shahid Bashir
    • English
    Non-invasive Brain Stimulation (NIBS) and Physiotherapy: Non-pharmacological Interventions for Neurological and Neuropsychiatric Disorders is the first book to provide an in-depth review of how rehabilitative therapy combined with Non-invasive Brain Stimulation (NIBS) can treat patients diagnosed with certain neurological and neuropsychiatric disorders. The book explores concepts in neuroanatomy, motor control, motor learning, and motor development. Each chapter covers mechanisms underlying the synergistic effects of NIBS and rehabilitative training on synaptic and network plasticity. Chapters considers the mechanisms of recovery with respect to neural plasticity and proposed targets for future trials, as well as protocol design.This book is a useful resource for developmental psychologists, physiotherapists, neurologists, and other researchers devoted to brain development and memory formation, as well as those working in the fields of molecular neurology and behavioral and biological sciences.

  • Kinase Targets and Drug Discovery

    • 1st Edition
    • Xiaoyun Lu
    • English
    Kinase Targets and Drug Discovery covers the critical role of kinases as regulators of cellular functions and their implications in a range of diseases, from cancers to cardiovascular disorders and inflammatory conditions. Readers will explore foundational concepts on the functions of kinases, the role of kinase inhibitors in disease therapy, and challenges faced. The second section focuses on innovative strategies in kinase drug discovery, covering screening and computational approaches, along with the development of covalent, macrocyclic, allosteric inhibitors, and kinase degraders. Final sections examine clinical applications, detailing how kinase inhibition can be harnessed for cancer therapies, non-oncologic diseases, and even non-catalytic functions.This book will serve as an indispensable resource for pharmacologists, medicinal chemists, and researchers in both academia and industry. By bridging the gap between foundational research and clinical application, it equips professionals with the latest insights and practical approaches to advance their understanding to contribute meaningfully to the evolving landscape of drug discovery.

  • A First Course in Model Validation and Model Risk Management

    • 1st Edition
    • Jonathan Schachter + 2 more
    • English
    A First Course in Model Validation and Model Risk Management offers robust coverage for current and future financial engineers. Useful as part of a masters program, for self-study, or as a valuable reference, the textbook explains in step-by-step, practical terms how mathematical models owned by financial institutions are essential to their public activities, including sales, trading, risk management, and internal audits. Like a diverse fleet of cars maintained by a rental car location, a bank must make sure customers can "drive" any of its models for a specific financial product. The book covers both pricing and risk models. Chapters consider modeling basics, marked-to-market and marked-to-model asset classes, market risk, credit risk, portfolio risk, operational risk, capital model risk, and financial crime, along with machine learning/AI.To support course use and practical applications, the text provides examples in Python throughout, as well as an appendix containing homework problems for all chapters, further supported by an ftp site for data and sample code. Additional appendices cover global model risk management, and a refresher in statistics.

  • Magnetic Resonance Fingerprinting for Quantitative MRI

    • 1st Edition
    • Volume 14
    • Dan Ma + 2 more
    • English
    MR Fingerprinting is emerging as a clinically feasible and versatile tool for quantitative MR imaging. Magnetic Resonance Fingerprinting for Quantitative MRI focuses on all aspects of MR Fingerprinting techniques and applications. Presenting a detailed and clear description of the technology, implementation, clinical translation issues and applications, it emphasizes different perspectives of MR signals and their utilization, with the goal of inspiring readers to explore new MR Fingerprinting designs. The book starts each section with a discussion on rethinking the MR acquisition and the opportunities provided by, for example, different MR contrast mechanisms, signal modeling, post-processing and clinical applications.Magneti... Resonance Fingerprinting for Quantitative MRI is a complete reference for magnetic resonance imaging researchers and radiologists.

  • Telehealth in Movement Disorders

    Principles, Strategies, Applications, and New Directions
    • 1st Edition
    • Wael Mohamed + 2 more
    • English
    The COVID-19 pandemic forced the world to pause and reevaluate how we operate specifically in medicine, shifting to telemedicine and telehealth. Integrating telemedicine and telehealth into the healthcare system enables patient safety and has been proven beneficial to medical and surgical practices including patient primary care. Telehealth in Movement Disorder: Principles, Strategies, Applications, and New Directions provides guidance on how to deliver clinical assessment and treatment to movements disorders patients through telemedicine. This book is divided into three distinct sections. The first section reviews general principles including strategies, standards, policies, and ethical aspects. The second section explores how telemedicine can be integrated into diagnosis, treatment, and care of patients with movement disorders including the use of new AI technologies. The final section discusses the integration and application of telemedicine in developing countries, including challenges and future opportunities.

  • Reverse Aging

    Current Research and Future Directions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.

  • Artificial Intelligence for Multi-omics Analysis Part A

    • 1st Edition
    • Volume 221
    • English
    Artificial Intelligence for Multi-omics Analysis, Part A, Volume 221 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as an Introduction to Artificial Intelligence in Multi-omics Analysis, Multi‐omics application in health and diseases, Artificial Intelligence in Genomics Analysis, Artificial Intelligence in Single-cell and Spatial Transcriptomics Data, Artificial Intelligence in the prediction of 3D chromatin structure and gene regulation, Artificial intelligence in Mass Spectrometry-based Proteomics, Integrating Artificial Intelligence into Metabolomics for Predicting Diseases, and more.Additional chapters cover Artificial Intelligence in Microbial Metagenomics, Artificial Intelligence in Interactomics, Artificial Intelligence Integration in Medical Imaging Data, AI in biomolecular structural data analysis, Artificial intelligence in Cryo-Electron Microscope data, Explainable artificial intelligence for multi-omics data, and Multi-Omics Cancer Stratification: from Statistical to Deep Learning Perspective.

  • From Conventional to Artificial Intelligence-Based Agriculture

    • 1st Edition
    • Vivek Sharma + 2 more
    • English
    From Conventional to Artificial Intelligence-Based Agriculture explores the evolving landscape of agriculture as it transitions from traditional practices to advanced, AI-driven solutions. With AI and machine learning revolutionizing industries worldwide, their impact on agriculture is becoming increasingly significant. These technologies are not only aiding in climate modeling but also opening new possibilities for precision farming, enabling more accurate crop health diagnostics, efficient resource management, and timely intervention strategies.By integrating conventional agricultural knowledge with cutting-edge AI tools, farmers and researchers can better assess soil conditions, predict optimal planting windows, monitor nutrient dynamics, and understand market trends with greater precision. This convergence of tradition and technology supports more resilient, productive, and sustainable agricultural systems, paving the way for a smarter and more food-secure future.

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