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Elsevier

Academic Press

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 8
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 8 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into seven chapters, this volume begins with an overview of the roles of multiple protein factors in the conversion of chitin synthetase zymogen to its catalytically active form. This text then examines the mechanisms that underlie differential metabolic control of the diverse functions of glucose-6-phosphatas... Other chapters consider the results of studies in Klebsiella aerogenes. This book discusses as well the physical–chemical properties of the enzymes from animals and bacteria. The final chapter deals with the mechanisms of regulating lipogenesis in animal tissues, the deamidation of glutamyl and asparaginyl residues in peptides and proteins. This book is a valuable resource for biochemists, biologists, and research workers.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 1
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • Lymphocyte Differentiation, Recognition, and Regulation

    • 1st Edition
    • David H. Katz
    • F. J. Dixon + 1 more
    • English
    Lymphocyte Differentiation, Recognition, and Regulation provides an overview of the state of knowledge on cellular immunology. The focus is on animal work than on studies in man, although in certain areas human lymphocyte biology has been discussed in some detail. The book attempts to integrate information from diverse areas of cellular immunology, immunogenetics, and immunochemistry to form some cohesive concepts that can be perhaps utilized as a working foundation for students and investigators in various areas of immunology. The book begins with a general description of some of techniques and principles underlying the systems frequently employed in cellular immunology. This is followed by detailed analyses of lymphocyte differentiation, receptor function, and regulatory processes. The main points that emerge from such analyses are that the immune system is an infinitely complex and finely tuned network of cells, receptors, and molecules which interact with one another in a genetically controlled manner that is manifested ultimately in the process known as differentiation.

  • Cell Structure and Function by Microspectrofluorometry

    • 1st Edition
    • Elli Kohen
    • English
    Cell Structure and Function by Microspectrofluorome... provides an overview of the state of knowledge in the study of cellular structure and function using microspectrofluorome... The book is organized into six parts. Part I begins by tracing the origins of modern fluorescence microscopy and fluorescent probes. Part II discusses methods such as microspectroscopy and flow cytometry; the fluorescence spectroscopy of solutions; and the quantitative implementation of fluorescence resonance energy transfer (FRET) in the light microscope. Part III presents studies on metabolism, including the mechanism of action of xenobiotics; biochemical analysis of unpigmented single cells; and cell-to-cell communication in the endocrine and the exocrine pancreas. Part IV focuses on applications of fluorescent probes. Part V deals with cytometry and cell sorting. It includes studies on principles and characteristics of flow cytometry as a method for studying receptor-mediated endocytosis; and flow cytometric measurements of physiologic cell responses. Part VI on bioluminescence discusses approaches to measuring chemiluminescence or bioluminescence in a single cell and measuring light emitted by living cells.

  • Electron and Positron Spectroscopies in Materials Science and Engineering

    Materials Science and Technology
    • 1st Edition
    • Otto Buck + 2 more
    • English
    Electron and Positron Spectroscopies in Materials Science and Engineering presents the advances and limitations of instrumentations for surface and interface probing useful to metallurgical applications. It discusses the Auger electron spectroscopy and electron spectroscopy for chemical analysis. It addresses the means to determine the chemistry of the surface. Some of the topics covered in the book are the exo-electron emission; positron annihilation; extended x-ray absorption fine structure; high resolution electron microscopy; uniaxial monotonic deformation-induced dislocation substructure; and analytical electron microscopy. The mechanistic basis for exo-electron spectroscopy is covered. The correlation of fatigue and photoyield are discussed. The text describes the tribostimulated emission. A study of the quantitative measurement of fatigue damage is presented. A chapter is devoted to the fracture of oxide films on aluminium. Another section focuses on the positron annihilation experimental details and the creep-induced dislocation substructure. The book can provide useful information to scientists, engineers, students, and researchers.

  • From Metabolite, to Metabolism, to Metabolon

    • 1st Edition
    • Volume 33
    • Earl R. Stadtman + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 33: From Metabolite, to Metabolism, to Metabolon is a collection of articles on the study of the machinery of the living cell. The book is also a tribute to Paul Srere, an eminent biochemist, on the occasion of his sixty-fifth birthday. The book contains contributions written by students, postdoctoral fellows, and biochemists within Paul Srere's broad sphere of influence. The text provides articles that discuss topics on cellular infrastructure and metabolic organization; how carbohydrates cross the lipid membrane of bacterial cells; and macromolecular processes. The structural aspects of citrate biochemistry; the electron transport systems; nucleotide biosynthesis; enzyme organization and the direction of metabolic flow; and bioengineering applications are tackled as well. Biochemists, cytologists, and cell biologists will find the book very insightful.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 23
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation: Volume 23 is a collection of papers that discusses pyruvate carboxylase, the regulation of carbohydrate metabolism, and the plasma membrane ATPase of fungi or plants. Other papers deal with adrenergic control of phosphofructokinase, protein phosphatase, as well as the regulation of polypeptide precursors of mature mitochondrial proteins. One paper explains the three dimensional structure of pyruvate carboxylase and its reaction mechanism. Electron microscopic analyses show that four monomers of pyruvate carboxylases isolated from vertebrate sources form a tight tetrahedron-like structure. Another paper describes the regulation of fructose 2,6-bisphosphate concentration in the liver and of the enzymes that are responsible for its metabolism, and the mechanism involved in fructose, particularly in the regulation of 6-phosphofructo-1-ki... and fructose-1,6-bisphos... activity. The paper also explains the role of this effector in the regulation of hepatic carbohydrate metabolism. One paper deals with the different levels of biological organization (whole cells, isolated plasma membranes, and purified enzyme) that characterizes the plasma membrane ATPase of fungi and plants as a novel type of proton pump. The collection can prove useful for biologists, microbiologists, students, and professors of biology and biophysics.

  • Immunodiffusion

    • 2nd Edition
    • Alfred J. Crowle
    • English
    Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

  • Techniques in Protein Chemistry

    Published Under the Auspices of the Protein Society
    • 1st Edition
    • John W. Crabb
    • English
    Techniques in Protein Chemistry V highlights current methods in peptide and protein mass spectrometry, sequence and amino acid analysis, fragmentations, separations, protein folding and modeling, peptide and protein NMR, and peptide synthesis. This volume emerged from the manuscripts presented at the Seventh Symposium of the Protein Society, held in San Diego on July 24-28, 1993. This volume is organized into eight parts encompassing 61 chapters. The first part surveys the peptide and protein characterization, detection, and analysis by mass spectrometry. The subsequent parts describe the structural characterization and analysis of posttranslational processing events, as well as the characterization of protein and amino acid sequences using several analytical techniques. Other parts explore other analytical methods for peptide and protein separations; some aspects involved in protein design and functional domain analysis; and the evaluation of protein conformation, folding, and modeling. The last parts contain research papers on NMR analysis of peptide and protein solution structures. These parts also look into topics related to peptide synthesis and peptide libraries. This book is intended primarily for protein and analytical chemists.

  • Speech and Language

    Advances in Basic Research and Practice
    • 1st Edition
    • Volume 10
    • Norman J. Lass
    • English
    Speech and Language: Advances in Basic Research and Practice, Volume 10 is a compendium of articles that discuss a wide range of topics on speech and language processes and pathologies. This volume contains seven papers presenting a broad range of topics on speech and language. The book provides various articles discussing topics on the articulatory and perceptual characteristics associated with apraxia of speech; prevention of communicative disorders in cleft palate infants; and the relationship between normal phonological acquisition and clinical intervention. Topics on the role of auditory timing in the diagnosis and treatment of speech and language disorders; categorical perception; and the theoretical and clinical implications of speakers' abilities to control the output of their speech mechanism are presented as well. Linguists, speech pathologists, and researchers on language development will find the book very insightful and informative.

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