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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Essays in Toxicology

    Volume 7
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 7 presents essays on toxicology and related topics. The book presents essays on the effects of toxicants on reproductive performance; an overall view of carcinogenesis from an epidemiological viewpoint and the potentialities and limitations of the epidemiological method in cancer control; and the activity of cytochrome P450 and mixed-function oxidase in target and nontarget organisms. The text also includes essays on the toxicity of hexachlorophene and the use of hexachlorophene as an antibacterial agent; the methodology, dose measurement, and respiratory function assessment in respiratory toxicology; as well as behavioral toxicology, with focus on early warning and worker safety and health. Pharmacologists, biochemists, pathologists, neurophysiologists, epidemiologists, and toxicologists will find the book invaluable.

  • Experimental and Comparative Toxicology

    • 1st Edition
    • Volume 31
    • Charles E. Cornelius + 1 more
    • English
    Experimental and Comparative Toxicology, Volume 31 aims to explore some of the potentially important and crucial areas in experimental toxicology. The book discusses tumor promoters and genotoxic chemicals in short-term testing for carcinogenicity, as well as the significance of preneoplastic liver lesions in experimental animals. The text also describes the factors known to be associated with increased risk of liver neoplasia as a human disease, and the extent to which it is known that the same factors have a similar effect in laboratory animals. Neurobehavioral toxicology; immunotoxicology; and the endocrine system as the target in experimental toxicology are also considered. The book further tackles the uses of gamma-glutamyltransf... in experimental toxicology, as well as the predictive value of ocular irritation tests. Toxicologists, biochemists, pathologists, and those involved in preventive medicine and community health will find the text invaluable.

  • Essays in Toxicology

    Volume 4
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

  • The Pathophysiology and Pharmacotherapy of Myocardial Infarction

    • 1st Edition
    • Nabil El-Sherif + 1 more
    • English
    The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related complications. This book covers two major consequences—cardiac muscle dysfunction and cardiac electrical dysfunction. This text begins by reviewing the controversy surrounding the pathogenetic mechanisms of atheroma formation and its potential reversibility, including the status of coronary risk factors and benefits of primary prevention. The pathophysiologic mechanisms of pump failure and the current approach to its management are then deliberated, followed by a discussion on the rational use of vasodilators in post-infarction heart failure and pharmacotherapy of cardiogenic shock. The rationale for the interest in the role of coronary vasospasm and thrombolytic therapy for acute myocardial infarction is also covered. This publication concludes by reviewing the approaches for the management of post-infarction ventricular tachyarrhythmias and concept of secondary prevention of sudden cardiac death. This compilation is valuable to medical students, primary care physicians, and cardiovascular specialists.

  • The Physiology and Pharmacology of the Microcirculation

    • 1st Edition
    • Nicholas A. Mortillaro
    • English
    The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.

  • Evaluation of Drug Activities

    Pharmacometrics
    • 1st Edition
    • D R Laurence + 1 more
    • English
    Evaluation of Drug Activities: Pharmacometrics, Volume 1 provides a review and critical discussion of general and special pharmacological methods used in the search of new drugs. This book discusses the fundamental difference between a pharmacological study and a bio-assay in the nature of the biological activity. Organized into two parts encompassing 19 chapters, this book begins with an overview of the pharmacological and toxicological studies on animals. This text then discusses the method of producing clinically successful drugs. Other chapters consider the objective of toxicity testing in determining the complications arising from the pharmacological action of the drug and also in discovering any unexpected side-effects. This book discusses as well the pharmacological effects and heredity in laboratory animals. The final chapter deals with the various aspects of hypertensive disease and its treatment. This book is a valuable resource for scientists, biologists, physiologists, pharmacologists, biochemists, physicians, clinicians, and research workers.

  • The Hallucinogens

    • 1st Edition
    • A. Hoffer + 1 more
    • English
    The Hallucinogens attempts to provide a detailed description of the hallucinogens in a single volume. Hallucinogens are chemicals which in nontoxic doses produce changes in perception, in thought, and in mood, but which seldom produce mental confusion, memory loss, or disorientation for person, place, and time. These latter changes are characteristic of organic brain reactions following intoxications with alcohol, anesthetics, and other toxic drugs. The book covers the following hallucinogens: plant ß-phenethylamines, d-lysergic acid diethylamide, ololiuqui, indole hallucinogens derived from tryptophan, and taraxein. The discussions include their chemistry, biochemistry, and neurophysiological effects. The final chapter deals with animal studies with hallucinogenic drugs. This work has been written for chemists, biochemists, psychologists, sociologists, and research physicians. While it cannot satisfy each group fully, it is sufficiently comprehensive and well documented so that each group can use it as a springboard for future enquiry into these fascinating chemicals.

  • Drug Safety

    Progress and Controversies
    • 1st Edition
    • Michel Auriche + 2 more
    • English

  • Mutagenicity

    New Horizons in Genetic Toxicology
    • 1st Edition
    • John A. Heddle
    • English
    Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.

  • Mechanisms of Drug Resistance in Neoplastic Cells

    Bristol-Myers Cancer Symposia, Vol. 9
    • 1st Edition
    • Paul V. Woolley + 1 more
    • English
    Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.

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